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Novel Psychoactive Substances (NPS) are a broad variety of drugs not regulated by present
legislation. The advent of NPS has contributed to the appearance and growth of a new ‘drug scenario’ characterized by an increased number of drug users among youth and the consumption of drugs with unknown effects or safety profiles. Preclinical and clinical findings have shown that at lower doses NPS may produce effects comparable to those of illicit psychoactive drugs, such as Cannabis, heroin, cocaine and MDMA, however, with more severe consequences